SCHEMBL21760179

SCHEMBL21760179

CN1C(=O)CNc2cc(I)ccc21

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRPF1 P55201 1/20 0.60
CASP3 P42574 1/20 0.44
ALDH1A1 P00352 2/20 0.36
GAA P10253 1/20 0.36
BRD4 O60885 2/20 0.34
APP P05067 1/20 0.33
CYP11B1 P15538 2/20 0.33
CYP11B2 P19099 2/20 0.33
PABPC1 P11940 1/20 0.33
APOBEC3A P31941 1/20 0.33
APOBEC3G Q9HC16 1/20 0.33
SRD5A1 P18405 1/20 0.32
LMNA P02545 1/20 0.32
TGM2 P21980 1/20 0.32
CES1 P23141 1/20 0.32
CYP17A1 P05093 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP19A1 P11511 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
HDAC1 Q13547 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2759567 0.81 CASP3 (0.53) BRPF1CASP3GAAAPPPABPC1
SCHEMBL11120910 0.80 BRPF1 (0.60) BRPF1ALDH1A1GAABRD4LMNA
SCHEMBL4476006 0.75 BRPF1 (1.00) BRPF1ALDH1A1GAABRD4PABPC1
SCHEMBL30537994 0.75 BRPF1 (1.00) BRPF1ALDH1A1GAABRD4PABPC1
SCHEMBL13089147 0.71 BRPF1 (0.62) BRPF1ALDH1A1GAABRD4SRD5A1
SCHEMBL6705947 0.71 CASP3 (0.49) BRPF1CASP3APPCYP11B1CYP11B2
SCHEMBL1879990 0.71 CYP11B1 (0.64) BRPF1CYP11B1CYP11B2SRD5A1CYP17A1
SCHEMBL16506973 0.70 TRIM24 (0.49) CASP3ALDH1A1GAALMNA
SCHEMBL20571810 0.70 BRPF1 (0.60) BRPF1ALDH1A1GAABRD4SRD5A1
SCHEMBL22050042 0.70 BRPF1 (0.60) BRPF1ALDH1A1GAABRD4SRD5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3807274-B1 4-SUBSTITUTED PYRROLO[2,3-B]PYRIDINE AS ERBB MODULATORS USEFUL FOR TREATING CANCER LEAD DISCOVERY CENTER GMBH (DE) 2022-07-27 EP disclosed
WO-2020039060-A1 4-SUBSTITUTED PYRROLO[2,3-B]PYRIDINE AS ERBB MODULATORS USEFUL FOR TREATING CANCER LEAD DISCOVERY CENTER GMBH (DE) 2020-02-27 WO disclosed
EP-3613738-A1 4-SUBSTITUTED PYRROLO[2,3-B]PYRIDINE AS ERBB MODULATORS USEFUL FOR TREATING CANCER Lead Discovery Center GmbH (DE) 2020-02-26 EP disclosed