Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.45 |
| ▸ | TDP2 | O95551 | 2/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14481009 | 0.83 | GABRA1 (0.50) | BRPF1PABPC1APOBEC3AAPOBEC3GTGM2 | |
| SCHEMBL4818630 | 0.81 | GABRA1 (0.45) | BRPF1PABPC1APOBEC3AAPOBEC3GCLK4 | |
| SCHEMBL7002012 | 0.81 | NR1H2 (0.48) | BRPF1PABPC1APOBEC3AAPOBEC3GCLK4 | |
| SCHEMBL607738 | 0.81 | LMNA (0.51) | BRPF1CA12CA9NTRK1FLT3 | |
| SCHEMBL21760179 | 0.81 | BRPF1 (0.60) | CASP3BRPF1PABPC1APOBEC3AAPOBEC3G | |
| SCHEMBL14552559 | 0.78 | CLK4 (0.46) | BRPF1PABPC1APOBEC3AAPOBEC3GCLK4 | |
| SCHEMBL1364964 | 0.77 | BRPF1 (0.64) | CASP3BRPF1PABPC1APOBEC3AAPOBEC3G | |
| SCHEMBL7556897 | 0.77 | CASP3 (0.57) | CASP3BRPF1TDP2GABRA1GABRG2 | |
| Ammonia Solution, Strong SCHEMBL9389187 | 0.76 | BRPF1 (0.62) | CASP3BRPF1PABPC1APOBEC3AAPOBEC3G | |
| SCHEMBL30833278 | 0.76 | CASP3 (0.57) | CASP3TDP2GSK3BAPPGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088759-B2 | 1,4-benzodiazepine-2,5-diones with therapeutic properties | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-01-03 | — | — | US | disclosed |