Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.58 |
| ▸ | KDR | P35968 | 10/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.58 |
| ▸ | FBP1 | P09467 | 2/20 | 0.58 |
| ▸ | CLK1 | P49759 | 2/20 | 0.58 |
| ▸ | RET | P07949 | 2/20 | 0.58 |
| ▸ | KIF5B | P33176 | 2/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | INSR | P06213 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
| ▸ | FLT4 | P35916 | 1/20 | 0.58 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.58 |
| ▸ | TEK | Q02763 | 1/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.58 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.58 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.58 |
| ▸ | DUS2 | Q9NX74 | 1/20 | 0.58 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18862875 | 0.89 | EGFR (0.75) | EGFRKDRERBB2FBP1CLK1 | |
| SCHEMBL12846249 | 0.82 | EGFR (0.64) | EGFRKDRERBB2FBP1CLK1 | |
| SCHEMBL18862756 | 0.80 | EGFR (0.58) | EGFRKDRERBB2RETFLT4 | |
| SCHEMBL19220799 | 0.80 | KDR (0.73) | EGFRKDRERBB2FBP1CLK1 | |
| SCHEMBL18632967 | 0.79 | FBP1 (0.76) | EGFRKDRERBB2FBP1CLK1 | |
| SCHEMBL24948889 | 0.79 | EGFR (0.66) | EGFRKDRERBB2FBP1CLK1 | |
| SCHEMBL10108265 | 0.79 | EGFR (0.72) | EGFRERBB2RETPDGFRBRIPK2 | |
| SCHEMBL25707230 | 0.78 | RET (0.68) | EGFRKDRERBB2FBP1CLK1 | |
| SCHEMBL15781191 | 0.78 | EGFR (0.67) | EGFRERBB2RIPK2ERBB3DUS2 | |
| SCHEMBL21473661 | 0.78 | KDR (0.70) | EGFRKDRERBB2FBP1CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022186-B1 | QUINAZOLINE DERIVATIVES, COMPOSITIONS THEREOF, AND USE AS PHARMACEUTICALS | SHANGHAI FOCHON PHARMACEUTICAL CO LTD (CN) | 2020-02-26 | — | — | EP | disclosed |