Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL819456 | 0.86 | CES2 (0.43) | CES2CA1CA2MAPTNPSR1 | |
| SCHEMBL13623436 | 0.81 | CES2 (0.46) | CES2CA1CA2MAPTNPSR1 | |
| SCHEMBL13404445 | 0.76 | LOX (0.35) | CES2CA1CA2MAPTNPSR1 | |
| SCHEMBL10157178 | 0.76 | PTGS1 (0.36) | CES2CA1CA2MAPTNPSR1 | |
| SCHEMBL10068845 | 0.74 | CES2 (0.48) | CES2CA1CA2MAPTNPSR1 | |
| SCHEMBL3507443 | 0.73 | CES2 (0.52) | CES2CA1CA2MAPTNPSR1 | |
| SCHEMBL13018927 | 0.73 | HSD11B1 (0.40) | CES2CA1CA2MAPTNPSR1 | |
| SCHEMBL28753502 | 0.72 | CES2 (0.50) | CES2CA1CA2MAPTNPSR1 | |
| SCHEMBL7419004 | 0.71 | CES2 (0.40) | CES2CA1CA2MAPTHDAC8 | |
| SCHEMBL13063654 | 0.71 | CES2 (0.45) | CES2CA1CA2MAPTHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10889579-B2 | Thiazine derivatives as β-secretase inhibitors and methods of use | AMGEN INC. (US) | 2021-01-12 | — | — | US | disclosed |
| US-20200062743-A1 | THIAZINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND METHODS OF USE | AMGEN INC. (US) | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10889579-B2 | Thiazine derivatives as β-secretase inhibitors and methods of use | BACE1, BACE2, APP | CES2 562/4885CA1 408/4885CA2 1509/4885 |
| US-20200062743-A1 | THIAZINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND METHODS OF USE | BACE1, BACE2, APP | CES2 719/4885CA1 485/4885CA2 1635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.