Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | ERN1 | O75460 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12674860 | 0.81 | ERN1 (0.72) | ATMNPSR1TSHRERN1 | |
| SCHEMBL21763645 | 0.75 | L3MBTL1 (0.56) | HRH4TSHRERN1HPGDKDM4E | |
| SCHEMBL12675653 | 0.72 | ERN1 (0.60) | ATMNPSR1TSHRERN1HPGD | |
| SCHEMBL12675423 | 0.70 | ERN1 (0.71) | ATMNPSR1ERN1 | |
| SCHEMBL18071180 | 0.69 | HRH4 (1.00) | HRH4TSHRHPGDNPC1RAB9A | |
| SCHEMBL21763657 | 0.69 | ERN1 (0.49) | HRH4ERN1NPC1RAB9AKDM4E | |
| SCHEMBL15846941 | 0.67 | TSHR (0.45) | HRH4ATMNPSR1TSHRHPGD | |
| SCHEMBL12121414 | 0.66 | HPGD (0.62) | HRH4ERN1HPGDNPC1RAB9A | |
| SCHEMBL9050585 | 0.66 | MAPT (0.61) | HRH4NPSR1TSHRNPC1RAB9A | |
| SCHEMBL18904579 | 0.65 | RIPK1 (0.81) | HRH4HPGDNPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496230-B1 | IRE-1 ALPHA INHIBITORS | FOSUN ORINOVE PHARMATECH INC (CN) | 2020-02-26 | — | — | EP | disclosed |