Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ERN1 | O75460 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 4/20 | 0.52 |
| ▸ | BCR | P11274 | 4/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21763595 | 0.86 | ERN1 (0.60) | L3MBTL1KDM4EERN1ABL1BCR | |
| SCHEMBL19961492 | 0.79 | ERN1 (0.80) | L3MBTL1KDM4EERN1 | |
| SCHEMBL13551840 | 0.79 | ERN1 (0.56) | L3MBTL1KDM4EERN1ABL1BCR | |
| SCHEMBL21763363 | 0.75 | HRH4 (0.52) | KDM4EERN1HPGDTSHRHRH4 | |
| SCHEMBL30885229 | 0.74 | L3MBTL1 (0.56) | L3MBTL1KDM4EERN1PIK3CDPIK3CA | |
| SCHEMBL27201480 | 0.74 | L3MBTL1 (0.56) | L3MBTL1KDM4EERN1PIK3CDPIK3CA | |
| SCHEMBL10094624 | 0.73 | ADORA2A (0.58) | L3MBTL1KDM4EERN1HPGDTSHR | |
| SCHEMBL10723960 | 0.72 | HPGD (0.68) | L3MBTL1KDM4EHPGDTSHR | |
| SCHEMBL16199135 | 0.72 | L3MBTL1 (1.00) | L3MBTL1KDM4EERN1PIK3CDPIK3CA | |
| SCHEMBL13618033 | 0.71 | L3MBTL1 (0.61) | L3MBTL1KDM4EERN1ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496230-B1 | IRE-1 ALPHA INHIBITORS | FOSUN ORINOVE PHARMATECH INC (CN) | 2020-02-26 | — | — | EP | disclosed |