Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 8/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 4/20 | 0.47 |
| ▸ | BCR | P11274 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21763645 | 0.86 | L3MBTL1 (0.56) | ERN1L3MBTL1KDM4EPIK3CDPIK3CA | |
| SCHEMBL21763695 | 0.85 | ERN1 (0.54) | ERN1L3MBTL1KDM4EPIK3CDPIK3CA | |
| SCHEMBL19961492 | 0.83 | ERN1 (0.80) | ERN1L3MBTL1KDM4E | |
| SCHEMBL21763657 | 0.78 | ERN1 (0.49) | ERN1L3MBTL1KDM4EPIK3CDPIK3CA | |
| SCHEMBL13551840 | 0.77 | ERN1 (0.56) | ERN1L3MBTL1KDM4EPIK3CDPIK3CA | |
| SCHEMBL21763560 | 0.76 | ERN1 (0.70) | ERN1MAPT | |
| SCHEMBL21763580 | 0.76 | HPGD (0.51) | ERN1KDM4EKCNH2HPGDTSHR | |
| SCHEMBL12767165 | 0.75 | ERN1 (1.00) | ERN1L3MBTL1KDM4E | |
| SCHEMBL30406594 | 0.73 | ERN1 (0.73) | ERN1L3MBTL1KDM4EPIK3CDPIK3CA | |
| SCHEMBL14916071 | 0.73 | ERN1 (0.73) | ERN1L3MBTL1KDM4EPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496230-B1 | IRE-1 ALPHA INHIBITORS | FOSUN ORINOVE PHARMATECH INC (CN) | 2020-02-26 | — | — | EP | disclosed |