Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.68 |
| ▸ | NPC1 | O15118 | 8/20 | 0.68 |
| ▸ | NAMPT | P43490 | 1/20 | 0.67 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.60 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.56 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5492048 | 0.86 | RAB9A (0.75) | RAB9ANPC1NAMPTKCNK9KCNK3 | |
| SCHEMBL95125 | 0.86 | NAMPT (0.61) | RAB9ANPC1NAMPTALDH1A1SMN1; SMN2 | |
| SCHEMBL28922759 | 0.84 | RAB9A (0.66) | RAB9ANPC1NAMPTKCNK9KCNK3 | |
| SCHEMBL5724139 | 0.84 | NAMPT (0.66) | RAB9ANPC1NAMPTKCNK9KCNK3 | |
| SCHEMBL6809719 | 0.82 | RAB9A (0.64) | RAB9ANPC1KCNK9KCNK3ALDH1A1 | |
| SCHEMBL21357031 | 0.82 | NPC1 (0.74) | RAB9ANPC1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5494349 | 0.82 | MAPT (0.65) | RAB9ANPC1KCNK9KCNK3ALDH1A1 | |
| SCHEMBL5931267 | 0.81 | NAMPT (0.48) | RAB9ANPC1NAMPTALDH1A1KDM4E | |
| SCHEMBL7050973 | 0.81 | KCNK9 (0.67) | RAB9ANPC1KCNK9KCNK3ALDH1A1 | |
| SCHEMBL18516263 | 0.81 | MET (0.55) | RAB9ANPC1NAMPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110172203-A1 | Substituted Imidazopyridinyl-Aminopyridine Compounds | ARQULE, INC. (US) | 2011-07-14 | — | — | US | disclosed |
| WO-2011082270-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ARQULE. INC. (US) | 2011-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172203-A1 | Substituted Imidazopyridinyl-Aminopyridine Compounds | MKI67, CDK4, ABL1 | RAB9A 2076/4885NPC1 1758/4885NAMPT 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.