Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 6/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14907883 | 0.82 | GRK6 (0.60) | GRK6MAPTSLC9A1DHODHSMN1; SMN2 | |
| SCHEMBL21763964 | 0.75 | REN (0.36) | TSHRSMN1; SMN2MEN1ALDH1A1POLB | |
| SCHEMBL21763962 | 0.73 | IKBKE (0.39) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL14907862 | 0.69 | GRK6 (0.45) | GRK6SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL23527364 | 0.67 | ALDH1A1 (0.48) | MAPTTSHRSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL31140771 | 0.67 | ALDH1A1 (0.48) | MAPTTSHRSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL18540022 | 0.67 | KDM4E (0.38) | GRK6MAPTSLC9A1 | |
| SCHEMBL21763938 | 0.66 | GRK6 (0.49) | GRK6MEN1KMT2A | |
| SCHEMBL13831003 | 0.64 | MEN1 (0.59) | MAPTTSHRMEN1ALDH1A1POLB | |
| SCHEMBL1436397 | 0.64 | SLC9A1 (0.39) | GRK6GRIN2BSLC9A1DHODHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134390-B1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUND MEDICAL EDUCATION & RES (US) | 2020-02-26 | — | — | EP | disclosed |