Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24492934 | 0.76 | BRD4 (0.39) | GABRA1GABRB2ELANE | |
| SCHEMBL21334962 | 0.76 | AHR (0.32) | AHR | |
| SCHEMBL1692142 | 0.75 | GABRA1 (0.47) | GABRA1GABRB2AHR | |
| SCHEMBL18237938 | 0.73 | AHR (0.34) | AHR | |
| SCHEMBL3973324 | 0.73 | TRPA1 (0.33) | — | |
| SCHEMBL31439785 | 0.71 | ALDH1A1 (0.32) | AHR | |
| SCHEMBL14438031 | 0.70 | AHR (0.38) | AHR | |
| SCHEMBL26290442 | 0.69 | TNF (0.33) | GABRA1GABRB2AHR | |
| SCHEMBL14113388 | 0.68 | CYP11B1 (0.44) | GABRA1GABRB2ELANE | |
| SCHEMBL25819938 | 0.68 | HTR2A (0.38) | GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200062776-A1 | HEDGEHOG ACYLTRANSFERASE INHIBITORS AND USES THEREOF | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200062776-A1 | HEDGEHOG ACYLTRANSFERASE INHIBITORS AND USES THEREOF | HHAT, SHH, MBOAT1 | GABRA1 2116/4885GABRB2 2040/4885AHR 473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.