Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 6/20 | 0.37 |
| ▸ | WNT3A | P56704 | 6/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11027048 | 1.00 | PTPN1 (0.38) | PTPN1ERCC5FEN1CTNNB1WNT3A | |
| SCHEMBL11027709 | 0.92 | CES2 (0.35) | PTPN1ERCC5FEN1CTNNB1WNT3A | |
| SCHEMBL20096960 | 0.87 | TK1 (0.33) | CASP3SENP7SENP6KMT2AMEN1 | |
| SCHEMBL20096959 | 0.87 | TK1 (0.33) | CASP3SENP7SENP6KMT2AMEN1 | |
| SCHEMBL19877975 | 0.87 | PTGDR2 (0.32) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL18011776 | 0.87 | PTGDR2 (0.32) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL11890492 | 0.86 | KIF11 (0.33) | KIF11 | |
| SCHEMBL21764442 | 0.84 | KIF11 (0.31) | KIF11 | |
| SCHEMBL14878499 | 0.84 | KIF11 (0.31) | KIF11 | |
| SCHEMBL20875702 | 0.82 | TSHR (0.36) | CASP3SENP7SENP6ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200062773-A1 | 4,4a,5,7-TETRAHYDRO-3H-FURO[3,4-b]PYRIDINYL COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200062773-A1 | 4,4a,5,7-TETRAHYDRO-3H-FURO[3,4-b]PYRIDINYL COMPOUNDS | BACE1, APP, PSEN1 | PTPN1 3679/4885ERCC5 2020/4885FEN1 663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.