Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 8/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.49 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21766054 | 0.90 | SLC13A5 (0.62) | EPHX2PKMPLA2G1BATG4BALDH1A1 | |
| SCHEMBL21766077 | 0.90 | KMT2A (0.50) | PKMPLA2G1BATG4BTP53ALDH1A1 | |
| SCHEMBL21766072 | 0.82 | EPHX2 (0.54) | EPHX2PKMPLA2G1BATG4BTP53 | |
| SCHEMBL20258851 | 0.80 | HPGD (0.42) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL21765928 | 0.76 | TP53 (0.82) | EPHX2PKMTP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL21765931 | 0.76 | SLC13A5 (0.82) | EPHX2TP53ALDH1A1SLC13A5MEN1 | |
| SCHEMBL21766082 | 0.76 | TP53 (0.66) | EPHX2PKMTP53ALDH1A1CYP3A4 | |
| SCHEMBL21766055 | 0.74 | SLC13A5 (0.76) | EPHX2PKMPLA2G1BATG4BTP53 | |
| SCHEMBL21766087 | 0.74 | PKM (0.78) | EPHX2PKMPLA2G1BATG4BTP53 | |
| SCHEMBL21766065 | 0.73 | SLC13A5 (0.64) | PKMALDH1A1SMN1; SMN2SLC13A5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10793522-B2 | Sulfonamides as inhibitors of the uptake of extracellular citrate | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-10-06 | — | — | US | disclosed |
| US-20200062708-A1 | SULFONAMIDES AS INHIBITORS OF THE UPTAKE OF EXTRACELLULAR CITRATE | BOEHRINGER INGELHEIM PHARMA GBMH & CO KG (DE) | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200062708-A1 | SULFONAMIDES AS INHIBITORS OF THE UPTAKE OF EXTRACELLULAR CITRATE | CS, GLS, GLS2 | EPHX2 3210/4885PKM 452/4885PLA2G1B 3284/4885 |
| US-10793522-B2 | Sulfonamides as inhibitors of the uptake of extracellular citrate | CS, GLS, GLS2 | EPHX2 3210/4885PKM 452/4885PLA2G1B 3284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.