Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 3/20 | 0.72 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20258826 | 0.93 | TSHR (0.79) | CYP2C9CYP2C19CYP3A4CYP2D6TSHR | |
| SCHEMBL20258762 | 0.83 | KMT2A (0.76) | TSHRKMT2AALDH1A1LMNAMEN1 | |
| SCHEMBL21765932 | 0.82 | GAA (0.53) | CYP2C9CYP2C19CYP3A4CYP2D6TSHR | |
| SCHEMBL21766082 | 0.81 | TP53 (0.66) | CYP3A4TSHRKMT2AALDH1A1POLB | |
| SCHEMBL21766045 | 0.80 | KMT2A (0.54) | CYP2C9CYP2C19CYP3A4CYP2D6TSHR | |
| SCHEMBL21766075 | 0.79 | TP53 (0.55) | CYP2C9CYP2C19CYP3A4CYP2D6TSHR | |
| SCHEMBL20258827 | 0.78 | SLC13A5 (0.69) | TSHRKMT2AALDH1A1POLBLMNA | |
| SCHEMBL20258831 | 0.76 | KMT2A (0.56) | CYP2C19TSHRNPC1KMT2ATDP1 | |
| SCHEMBL13621146 | 0.76 | ALDH1A1 (0.74) | CYP2C9CYP2C19CYP3A4CYP2D6TSHR | |
| SCHEMBL21765928 | 0.76 | TP53 (0.82) | CYP2C9CYP2C19CYP3A4KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10793522-B2 | Sulfonamides as inhibitors of the uptake of extracellular citrate | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-10-06 | — | — | US | disclosed |
| US-20200062708-A1 | SULFONAMIDES AS INHIBITORS OF THE UPTAKE OF EXTRACELLULAR CITRATE | BOEHRINGER INGELHEIM PHARMA GBMH & CO KG (DE) | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200062708-A1 | SULFONAMIDES AS INHIBITORS OF THE UPTAKE OF EXTRACELLULAR CITRATE | CS, GLS, GLS2 | CYP2C9 950/4885CYP2C19 978/4885CYP3A4 1264/4885 |
| US-10793522-B2 | Sulfonamides as inhibitors of the uptake of extracellular citrate | CS, GLS, GLS2 | CYP2C9 950/4885CYP2C19 978/4885CYP3A4 1264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.