Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 6/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20189301 | 0.84 | APLNR (0.39) | APLNRGBA1ESR1ESR2MBOAT4 | |
| SCHEMBL20190068 | 0.84 | APLNR (0.39) | APLNRGBA1ESR1ESR2MBOAT4 | |
| SCHEMBL20189305 | 0.84 | APLNR (0.39) | APLNRGBA1ESR1ESR2MBOAT4 | |
| SCHEMBL18504964 | 0.81 | APLNR (0.50) | APLNRESR1ESR2CA2MBOAT4 | |
| SCHEMBL5344274 | 0.77 | GBA1 (0.46) | APLNRGBA1ESR1ESR2MBOAT4 | |
| SCHEMBL28895225 | 0.74 | GBA1 (0.39) | GBA1CA2MBOAT4KDM4EALDH1A1 | |
| SCHEMBL14464977 | 0.74 | GBA1 (0.43) | GBA1ESR1ESR2MBOAT4KDM4E | |
| SCHEMBL30305975 | 0.74 | GBA1 (0.43) | GBA1ESR1ESR2MBOAT4KDM4E | |
| SCHEMBL5144435 | 0.74 | GBA1 (0.43) | GBA1ESR1ESR2MBOAT4KDM4E | |
| SCHEMBL20177980 | 0.73 | APLNR (0.38) | APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3300500-B1 | TRIAZOLE AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2020-02-26 | — | — | EP | disclosed |