Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | FBP1 | P09467 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | MC5R | P33032 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25538982 | 0.79 | MAPK1 (0.58) | CYP1A2CYP2D6CYP2C19HIF1ACYP3A4 | |
| SCHEMBL18246186 | 0.79 | ALDH1A1 (0.46) | CYP1A2CYP2D6CYP2C19HIF1ACYP3A4 | |
| SCHEMBL19550816 | 0.79 | ALDH1A1 (0.46) | CYP1A2CYP2D6CYP2C19HIF1ACYP3A4 | |
| SCHEMBL18474682 | 0.79 | ALDH1A1 (0.46) | CYP1A2CYP2D6CYP2C19HIF1ACYP3A4 | |
| SCHEMBL22812956 | 0.79 | ALDH1A1 (0.46) | CYP1A2CYP2D6CYP2C19HIF1ACYP3A4 | |
| SCHEMBL10943607 | 0.78 | FBP1 (0.58) | CYP1A2CYP2D6CYP2C19HIF1ACYP3A4 | |
| SCHEMBL19551018 | 0.77 | ALDH1A1 (0.42) | CYP1A2CYP2D6CYP2C19HIF1ACYP3A4 | |
| SCHEMBL18246046 | 0.77 | ALDH1A1 (0.42) | CYP1A2CYP2D6CYP2C19HIF1ACYP3A4 | |
| SCHEMBL18246472 | 0.76 | ALDH1A1 (0.42) | CYP1A2CYP2D6CYP2C19HIF1ACYP3A4 | |
| SCHEMBL18246661 | 0.76 | ALDH1A1 (0.42) | CYP1A2CYP2D6CYP2C19HIF1ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3300500-B9 | TRIAZOLE AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2021-01-13 | — | — | EP | disclosed |
| EP-3300500-B1 | TRIAZOLE AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2020-02-26 | — | — | EP | disclosed |