Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Duroquinone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | S100A4 | P26447 | 2/20 | 0.31 |
| ▸ | CDC25A | P30304 | 2/20 | 0.31 |
| ▸ | CDC25B | P30305 | 2/20 | 0.31 |
| ▸ | MAOA | P21397 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Duroquinone SCHEMBL58325 | 0.80 | MAOA (0.38) | ALDH1A1DUSP3CDC25ACDC25BMAOA | |
| Duroquinone SCHEMBL11473070 | 0.76 | MAOA (0.36) | DUSP3MAOAMAOB | |
| SCHEMBL10446161 | 0.76 | ALOX15 (0.38) | CDC25BMAOAALOX15LMNAPGR | |
| SCHEMBL12744504 | 0.73 | ALOX15 (0.32) | DUSP3CDC25BMAOAALOX15LMNA | |
| Duroquinone SCHEMBL9134466 | 0.71 | MAOA (0.31) | MAOAMAOB | |
| SCHEMBL10295726 | 0.71 | ALOX15 (0.35) | ALDH1A1CDC25BALOX15MAPTTDP1 | |
| Alcohol SCHEMBL27641270 | 0.71 | — | — | |
| Duroquinone SCHEMBL11701942 | 0.67 | MAOA (0.38) | DUSP3CDC25ACDC25BMAOAMAOB | |
| Alcohol SCHEMBL27865039 | 0.66 | — | — | |
| Alcohol SCHEMBL2464657 | 0.66 | TSHR (1.00) | ALDH1A1TSHRLMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11713479-B2 | Method for determining whether or not test sample contains phytopathogenic fungus | PANASONIC INTRILECTUAL PROPERTY MANAGEMENT CO., LTD. (JP) | 2023-08-01 | — | — | US | disclosed |
| CN-115589740-A | Quantum dot device and preparation method thereof | TCL科技集团股份有限公司 | 2023-01-10 | — | — | CN | disclosed |
| EP-3617319-B1 | METHOD FOR DETERMINING PRESENCE OR ABSENCE OF PHYTOPATHOGENIC MICROBE IN TEST SAMPLE | PANASONIC IP MAN CO LTD (JP) | 2022-12-07 | — | — | EP | disclosed |
| US-20210340588-A1 | METHOD FOR DETERMINING WHETHER OR NOT TEST SAMPLE CONTAINS PHYTOPATHOGENIC FUNGUS | PANASONIC IP MAN CO LTD (JP) | 2021-11-04 | — | — | US | disclosed |
| EP-3617319-A1 | METHOD FOR DETERMINING PRESENCE OR ABSENCE OF PHYTOPATHOGENIC MICROBE IN TEST SAMPLE | Panasonic Intellectual Property Management Co., Ltd. (JP) | 2020-03-04 | — | — | EP | disclosed |
| CN-110291204-A | Test sample whether the determination method containing plant-pathogenic bacterium | 松下知识产权经营株式会社 | 2019-09-27 | — | — | CN | disclosed |