Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.48 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.46 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 6/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 5/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.42 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16384695 | 0.91 | SMN1; SMN2 (0.53) | SIRT2CAPN1CAPN2SMN1; SMN2LMNA | |
| SCHEMBL17804044 | 0.81 | SMN1; SMN2 (0.53) | SIRT2CAPN1CAPN2SMN1; SMN2LMNA | |
| SCHEMBL25273831 | 0.76 | SIRT2 (0.59) | SIRT2CAPN1CAPN2SMN1; SMN2LMNA | |
| SCHEMBL25273830 | 0.76 | SIRT2 (0.59) | SIRT2CAPN1CAPN2SMN1; SMN2LMNA | |
| SCHEMBL30634608 | 0.76 | SMN1; SMN2 (0.53) | SIRT2CAPN1CAPN2SMN1; SMN2LMNA | |
| SCHEMBL15382100 | 0.75 | LMNA (0.57) | SIRT2CAPN1CAPN2SMN1; SMN2LMNA | |
| SCHEMBL25132765 | 0.74 | SYK (0.49) | SIRT2CAPN1CAPN2SMN1; SMN2LMNA | |
| SCHEMBL21422694 | 0.74 | SMN1; SMN2 (0.59) | SIRT2CAPN1CAPN2SMN1; SMN2LMNA | |
| SCHEMBL16384896 | 0.74 | SMN1; SMN2 (0.59) | SIRT2CAPN1CAPN2SMN1; SMN2LMNA | |
| SCHEMBL21769361 | 0.74 | CTSL (0.53) | SIRT2CAPN1CAPN2SIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613755-A1 | LYSINE-SPECIFIC CHEMOENZYMATIC PROTEIN MODIFICATIONS USING MICROBIAL TRANSGLUTAMINASE | Novartis AG (CH) | 2020-02-26 | — | — | EP | disclosed |