Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 4/20 | 0.44 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NMT1 | P30419 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18398582 | 0.84 | OPRK1 (0.48) | OPRK1DPP4HSD17B10POLBTSHR | |
| SCHEMBL15527865 | 0.84 | OPRK1 (0.48) | OPRK1DPP4HSD17B10POLBTSHR | |
| SCHEMBL21512801 | 0.82 | OPRK1 (0.46) | OPRK1DPP4HSD17B10POLBTSHR | |
| SCHEMBL31362502 | 0.81 | OPRK1 (0.37) | OPRK1KDM4ETSHRALDH1A1GAA | |
| SCHEMBL31390860 | 0.78 | OPRK1 (0.44) | OPRK1DPP4HSD17B10POLBTSHR | |
| SCHEMBL31390961 | 0.78 | OPRK1 (0.44) | OPRK1DPP4HSD17B10POLBTSHR | |
| SCHEMBL15527494 | 0.78 | OPRK1 (0.50) | OPRK1HSD17B10POLBTSHRNPSR1 | |
| SCHEMBL5864153 | 0.78 | OPRK1 (0.50) | OPRK1KDM4EHSD17B10POLBTSHR | |
| SCHEMBL10668140 | 0.77 | OPRK1 (0.49) | OPRK1HSD17B10POLBTSHRNPSR1 | |
| SCHEMBL5863951 | 0.76 | MAPKAPK2 (0.40) | DPP4KDM4EHSD17B10NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110325526-B | Isoquinoline and naphthyridine compounds | 伊莱利利公司 | 2021-11-19 | — | — | CN | disclosed |
| US-11117891-B2 | Isoquinolin and naphthydrin compounds | ELI LILLY AND COMPANY (US) | 2021-09-14 | — | — | US | disclosed |
| US-11117891-B2 | Isoquinolin and naphthydrin compounds | ELI LILLY AND COMPANY (US) | 2021-09-14 | — | — | US | disclosed |
| EP-3589625-B1 | ISOQUINOLIN AND NAPHTHYDRIN COMPOUNDS | LILLY CO ELI (US) | 2021-04-14 | — | — | EP | disclosed |
| EP-3589625-B1 | ISOQUINOLIN AND NAPHTHYDRIN COMPOUNDS | LILLY CO ELI (US) | 2021-04-14 | — | — | EP | disclosed |
| US-20200062751-A1 | ISOQUINOLIN AND NAPHTHYDRIN COMPOUNDS | ELI LILLY AND COMPANY | 2020-02-27 | — | — | US | disclosed |
| US-20200062751-A1 | ISOQUINOLIN AND NAPHTHYDRIN COMPOUNDS | ELI LILLY AND COMPANY | 2020-02-27 | — | — | US | disclosed |
| WO-2018160406-A1 | ISOQUINOLIN AND NAPHTHYDRIN COMPOUNDS | ELI LILLY AND COMPANY (US) | 2018-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11117891-B2 | Isoquinolin and naphthydrin compounds | SLC10A1, NQO1, SNX2 | OPRK1 2155/4885DPP4 2424/4885KDM4E 2787/4885 |
| US-20200062751-A1 | ISOQUINOLIN AND NAPHTHYDRIN COMPOUNDS | SLC10A1, NQO1, NPC1 | OPRK1 2006/4885DPP4 2462/4885KDM4E 2607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.