Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | CTSG | P08311 | 1/20 | 0.41 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21769865 | 0.86 | P2RX7 (0.66) | P2RX7LMNAGAA | |
| SCHEMBL21769900 | 0.82 | P2RX7 (0.72) | P2RX7EPHX2 | |
| SCHEMBL30848447 | 0.78 | LMNA (0.59) | P2RX7LMNAGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL25713063 | 0.75 | LMNA (0.60) | P2RX7LMNAGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL3454922 | 0.74 | P2RX7 (1.00) | P2RX7EPHX2 | |
| SCHEMBL2588306 | 0.73 | GAA (0.68) | LMNAGAASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL12856160 | 0.73 | LMNA (0.61) | P2RX7LMNAGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL1971598 | 0.72 | LMNA (0.52) | P2RX7LMNAGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL8640906 | 0.71 | LMNA (0.59) | P2RX7LMNAGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL30914523 | 0.71 | LMNA (0.59) | P2RX7LMNAGAASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020037350-A1 | ADAMANTANYL-SUBSTITUTED BENZAMIDE COMPOUNDS AND THEIR USE AS P2X7 RECEPTOR ANTAGONISTS | THE UNIVERSITY OF SYDNEY (AU) | 2020-02-27 | — | — | WO | disclosed |