SCHEMBL21770975

SCHEMBL21770975

Nc1cccc(-c2cccc(OC(F)(F)F)c2)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XDH P47989 1/20 0.51
MAOA P21397 1/20 0.50
ABL1 P00519 1/20 0.49
BCR P11274 1/20 0.49
ADORA1 P30542 3/20 0.47
ADORA2A P29274 1/20 0.47
KCNH2 Q12809 1/20 0.47
SCN10A Q9Y5Y9 1/20 0.47
PTGES2 Q9H7Z7 1/20 0.45
PIM1 P11309 1/20 0.45
PIM2 Q9P1W9 1/20 0.45
GALR1 P47211 1/20 0.44
DYRK1A Q13627 1/20 0.43
KIF11 P52732 1/20 0.43
MAP4K4 O95819 1/20 0.43
CTSD P07339 1/20 0.43
BACE1 P56817 1/20 0.43
BACE2 Q9Y5Z0 1/20 0.43
NPY5R Q15761 1/20 0.43
ALDH1A1 P00352 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1523 0.88 CYP3A4 (0.54) XDHABL1BCRKIF11ALDH1A1
SCHEMBL29366090 0.88 CYP3A4 (0.54) XDHABL1BCRKIF11ALDH1A1
SCHEMBL1241524 0.87 ABL1 (0.54) MAOAABL1BCRKIF11MAP4K4
SCHEMBL30363971 0.87 ABL1 (0.54) MAOAABL1BCRKIF11MAP4K4
SCHEMBL1337217 0.87 TAAR1 (0.52) XDHADORA1ADORA2AKCNH2SCN10A
Hydrochloric Acid SCHEMBL27585318 0.86 POLB (0.53) XDHABL1BCRKIF11ALDH1A1
Hydrochloric Acid SCHEMBL31174567 0.86 POLB (0.53) XDHABL1BCRKIF11ALDH1A1
SCHEMBL5840598 0.82 SLC13A5 (0.51) XDHADORA1ADORA2AKCNH2SCN10A
SCHEMBL2380991 0.82 XDH (0.49) XDHADORA1ADORA2AKCNH2SCN10A
SCHEMBL3277697 0.81 MAOB (0.60) XDHKIF11ALDH1A1CYP3A4TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11827616-B2 Heterocyclic compounds as pesticides DISCOVERY PURCHASER CORPORATION (US) 2023-11-28 US disclosed
US-20200062729-A1 NOVEL HETEROCYCLIC COMPOUNDS AS PESTICIDES DISCOVERY PURCHASER CORPORATION 2020-02-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11827616-B2 Heterocyclic compounds as pesticides DDT, CHRM1, ACHE XDH 514/4885MAOA 446/4885ABL1 4149/4885
US-20200062729-A1 NOVEL HETEROCYCLIC COMPOUNDS AS PESTICIDES CHRM1, DDT, ACHE XDH 888/4885MAOA 639/4885ABL1 4233/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.