Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 12/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | HTR1B | P28222 | 1/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | HTR2C | P28335 | 1/20 | 0.64 |
| ▸ | HTR2B | P41595 | 1/20 | 0.64 |
| ▸ | BACE1 | P56817 | 3/20 | 0.46 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1E | P28566 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29764273 | 1.00 | HTR1F (1.00) | HTR1FHTR1AHTR1BHTR2AHTR2C | |
| SCHEMBL29764278 | 0.89 | HTR1F (1.00) | HTR1FHTR1AHTR1BHTR2AHTR2C | |
| SCHEMBL21771025 | 0.89 | HTR1F (1.00) | HTR1FHTR1AHTR1BHTR2AHTR2C | |
| SCHEMBL21771024 | 0.89 | HTR1F (1.00) | HTR1FHTR1AHTR1BHTR2AHTR2C | |
| SCHEMBL29764248 | 0.89 | HTR1F (1.00) | HTR1FHTR1AHTR1BHTR2AHTR2C | |
| SCHEMBL23528947 | 0.84 | HTR1F (0.73) | HTR1FHTR1AHTR1BHTR2AHTR2C | |
| SCHEMBL29764240 | 0.84 | HTR1F (0.73) | HTR1FHTR1AHTR1BHTR2AHTR2C | |
| SCHEMBL21771022 | 0.83 | HTR1F (1.00) | HTR1FHTR1AHTR1BHTR2AHTR2C | |
| SCHEMBL28807277 | 0.83 | HTR1F (0.73) | HTR1FHTR1AHTR1BHTR2AHTR2C | |
| SCHEMBL29764243 | 0.82 | HTR1F (0.70) | HTR1FHTR1AHTR1BHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858910-B2 | Pyridinylmethylenepiperidine derivatives and uses thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2024-01-02 | — | — | US | disclosed |
| US-11858910-B2 | Pyridinylmethylenepiperidine derivatives and uses thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2024-01-02 | — | — | US | disclosed |
| US-11858910-B2 | Pyridinylmethylenepiperidine derivatives and uses thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2024-01-02 | — | — | US | disclosed |
| CN-110437205-B | Pyridinonylpiperidine derivatives and use thereof | 广东东阳光药业有限公司 | 2022-07-08 | — | — | CN | disclosed |
| US-20210188803-A1 | PYRIDINYLMETHYLENEPIPERIDINE DERIVATIVES AND USES THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2021-06-24 | — | — | US | disclosed |
| US-20210188803-A1 | PYRIDINYLMETHYLENEPIPERIDINE DERIVATIVES AND USES THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2021-06-24 | — | — | US | disclosed |
| WO-2020038435-A1 | PYRIDINYLMETHYLENEPIPERIDINE DERIVATIVES AND USES THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2020-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11858910-B2 | Pyridinylmethylenepiperidine derivatives and uses thereof | HTR1F, HTR1A, HTR5A | HTR1F 1/4885HTR1A 2/4885HTR1B 6/4885 |
| US-20210188803-A1 | PYRIDINYLMETHYLENEPIPERIDINE DERIVATIVES AND USES THEREOF | HTR1F, HTR1A, HTR5A | HTR1F 1/4885HTR1A 2/4885HTR1B 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.