Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | P2RY1 | P47900 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20428062 | 0.86 | ALDH1A1 (0.34) | PDE10AALDH1A1P2RY1DRD1RAB9A | |
| SCHEMBL23934738 | 0.86 | ALDH1A1 (0.37) | PDE10AALDH1A1P2RY1MEN1KMT2A | |
| SCHEMBL482170 | 0.82 | GAA (0.46) | PDE10AALDH1A1DRD1RAB9A | |
| SCHEMBL20428065 | 0.79 | PDE10A (0.32) | PDE10AALDH1A1RAB9A | |
| SCHEMBL23934732 | 0.77 | ALDH1A1 (0.39) | PDE10AALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL21771178 | 0.76 | ALDH1A1 (0.38) | PDE10AALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL21384474 | 0.76 | TLR7 (0.37) | PDE10AALDH1A1DRD1RAB9A | |
| SCHEMBL3878940 | 0.75 | PDE10A (0.43) | PDE10AALDH1A1MEN1KMT2ADRD1 | |
| SCHEMBL20428083 | 0.71 | ALDH1A1 (0.37) | PDE10AALDH1A1RAB9A | |
| SCHEMBL30181916 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689874-A1 | 1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS | H. Lundbeck A/S (DK) | 2020-08-05 | — | — | EP | disclosed |
| EP-3478681-B1 | 1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS | H LUNDBECK AS (DK) | 2020-02-26 | — | — | EP | disclosed |