Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | SLC13A5 | Q86YT5 | 3/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21771191 | 0.86 | PDE10A (0.36) | ALDH1A1PDE10AMEN1KMT2ATDP1 | |
| SCHEMBL482170 | 0.85 | GAA (0.46) | ALDH1A1PDE10ASMN1; SMN2GAADRD1 | |
| SCHEMBL20428062 | 0.81 | ALDH1A1 (0.34) | ALDH1A1PDE10ASMN1; SMN2GAADRD1 | |
| SCHEMBL21384474 | 0.79 | TLR7 (0.37) | ALDH1A1PDE10ASMN1; SMN2DRD1LMNA | |
| SCHEMBL20428065 | 0.74 | PDE10A (0.32) | ALDH1A1PDE10ASMN1; SMN2LMNA | |
| SCHEMBL610170 | 0.74 | — | — | |
| SCHEMBL30181916 | 0.74 | — | — | |
| SCHEMBL3878940 | 0.73 | PDE10A (0.43) | ALDH1A1PDE10ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL23934732 | 0.73 | ALDH1A1 (0.39) | ALDH1A1PDE10ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL21771178 | 0.71 | ALDH1A1 (0.38) | ALDH1A1PDE10ASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3723807-B1 | COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES | H LUNDBECK AS (DK) | 2021-10-20 | — | — | EP | disclosed |