Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21771178 | 0.91 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2GRM4LMNAPDE10A | |
| SCHEMBL20428083 | 0.87 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2GRM4LMNAPDE10A | |
| SCHEMBL1933518 | 0.80 | SCN9A (0.41) | ALDH1A1SMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL21771191 | 0.77 | PDE10A (0.36) | ALDH1A1PDE10ARAB9AMEN1KMT2A | |
| SCHEMBL12135760 | 0.74 | APP (0.45) | ALDH1A1SMN1; SMN2GRM4LMNAPDE10A | |
| SCHEMBL24599910 | 0.73 | ALDH1A1 (0.33) | ALDH1A1SMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL27194714 | 0.73 | SMN1; SMN2 (0.38) | ALDH1A1SMN1; SMN2GRM4LMNAPDE10A | |
| SCHEMBL1842773 | 0.73 | HPGD (0.53) | ALDH1A1SMN1; SMN2LMNAL3MBTL1NPC1 | |
| SCHEMBL23934738 | 0.73 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2GRM4LMNAPDE10A | |
| SCHEMBL24553667 | 0.73 | NPC1 (0.41) | ALDH1A1SMN1; SMN2GRM4LMNAPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3723807-B1 | COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES | H LUNDBECK AS (DK) | 2021-10-20 | — | — | EP | disclosed |
| EP-3723808-B1 | COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES | H LUNDBECK AS (DK) | 2021-10-20 | — | — | EP | disclosed |