Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL4076453 | 0.90 | — | — | |
| Tetrahydrofuran SCHEMBL1278401 | 0.90 | — | — | |
| Tetrahydrofuran SCHEMBL1512532 | 0.90 | — | — | |
| Tetrahydrofuran SCHEMBL29711634 | 0.90 | — | — | |
| Tetrahydrofuran SCHEMBL21496006 | 0.90 | — | — | |
| Tetrahydrofuran SCHEMBL7947125 | 0.90 | ALDH1A1 (0.80) | — | |
| Tetrahydrofuran SCHEMBL130914 | 0.89 | — | — | |
| Tetrahydrofuran SCHEMBL6298732 | 0.89 | — | — | |
| Tetrahydrofuran SCHEMBL1982618 | 0.89 | — | — | |
| SCHEMBL3455441 | 0.89 | ALDH1A1 (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4397664-A1 | PYRIMIDINE-FUSED CYCLIC COMPOUND AND PREPARATION METHOD AND USE THEREOF | Genfleet Therapeutics (Shanghai) Inc. (CN) | 2024-07-10 | — | — | EP | disclosed |
| US-11384057-B2 | Methods for preparing fuel additives | BP OIL INTERNATIONAL LIMITED (GB) | 2022-07-12 | — | — | US | disclosed |
| US-11230680-B2 | Methods for preparing fuel additives | BP OIL INTERNATIONAL LIMITED (GB) | 2022-01-25 | — | — | US | disclosed |
| US-20200332208-A1 | Methods for Preparing Fuel Additives | BP OIL INTERNATIONAL LIMITED (GB) | 2020-10-22 | — | — | US | disclosed |
| US-20200331869-A1 | Methods for Preparing Fuel Additives | BP OIL INTERNATIONAL LIMITED (GB) | 2020-10-22 | — | — | US | disclosed |
| EP-3042900-B1 | NOVEL MORPHOLINE DERIVATIVE OR SALT THEREOF | FUJIFILM CORP (JP) | 2020-09-23 | — | — | EP | disclosed |
| CN-106008569-B9 | Borate as arginase inhibitor and composition and application thereof | 马尔斯公司 | 2020-05-22 | — | — | CN | disclosed |
| CN-106008569-B | Borate as arginase inhibitor and composition and application thereof | 马尔斯公司 | 2020-04-03 | — | — | CN | disclosed |
| CN-106986875-A | The conditioning agent and its application method of 5 HT acceptors | ABBVIE 公司 | 2017-07-28 | — | — | CN | disclosed |
| CN-102482292-B | Modulators of 5-HT receptors and methods of use thereof | ABBVIE 公司 | 2017-07-18 | — | — | CN | disclosed |
| US-20060270738-A1 | Novel derivatives of 3,3-diphenylpropylamines | UCB PHARMA GMBH (DE) | 2006-11-30 | — | — | US | disclosed |
| CN-1690041-A | Novel derivatives of 3,3-diphenylpropylamines | SANOL ARZNEI SCHWARZ GMBH (DE) | 2005-11-02 | — | — | CN | disclosed |
| CN-1207268-C | 3, 3-diphenylpropylamine derivatives | SANOL ARZNEI SCHWARZ GMBH (DE) | 2005-06-22 | — | — | CN | disclosed |
| US-20040186061-A1 | Novel derivatives of 3,3-diphenylpropylamines | SCHWARZ PHARMA AG | 2004-09-23 | — | — | US | disclosed |
| US-6713464-B1 | ANTIMUSCARINIC AGENTS WITH SUPERIOR PHARMACOKINETICS | SCHWARZ PHARMA AG (DE) | 2004-03-30 | — | — | US | disclosed |
| EP-1254890-A1 | Derivatives of 3,3-diphenylpropylamines | SCHWARZ PHARMA AG (DE) | 2002-11-06 | — | — | EP | disclosed |
| CN-1354737-A | Novel 3, 3-diphenylpropylamine derivatives | SANOL ARZNEI SCHWARZ GMBH (DE) | 2002-06-19 | — | — | CN | disclosed |
| WO-2001045704-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-06-28 | — | — | WO | disclosed |
| WO-1998007722-A1 | QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONIST | PFIZER LIMITED (GB) | 1998-02-26 | — | — | WO | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |