Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21749163 | 1.00 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL20502077 | 1.00 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL21775861 | 0.93 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL21775783 | 0.93 | ABCB1 (0.41) | ALDH1A1KDM4EHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL21774116 | 0.92 | ALDH1A1 (0.41) | ALDH1A1KDM4EHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL21775681 | 0.92 | ABCB1 (0.45) | ALDH1A1KDM4EHPGDSMN1; SMN2HTT | |
| SCHEMBL21775506 | 0.92 | ABCB1 (0.42) | ALDH1A1KDM4EHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL21774098 | 0.91 | DPP4 (0.40) | ALDH1A1KDM4EHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL21774114 | 0.91 | HPGD (0.41) | ALDH1A1KDM4EHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL21775634 | 0.91 | DPP4 (0.40) | ALDH1A1KDM4EHPGDSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10960007-B2 | Pharmacologically active aryl-substituted pyrazolo[1,5-a]pyrimidine derivatives | RICHTER GEDEON NYRT. (HU) | 2021-03-30 | — | — | US | disclosed |
| US-20200061068-A1 | Pharmacologically Active Aryl-Substituted Pyrazolo[1,5-a]Pyrimidine Derivatives | RICHTER GEDEON NYRT. (HU) | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200061068-A1 | Pharmacologically Active Aryl-Substituted Pyrazolo[1,5-a]Pyrimidine Derivatives | GABRA5, P2RX5, P2RY1 | ALDH1A1 585/4885KDM4E 2972/4885HPGD 1684/4885 |
| US-10960007-B2 | Pharmacologically active aryl-substituted pyrazolo[1,5-a]pyrimidine derivatives | GABRA5, P2RX5, P2RY1 | ALDH1A1 585/4885KDM4E 2972/4885HPGD 1684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.