Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | BID | P55957 | 3/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.35 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.35 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.35 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9815065 | 0.90 | MEN1 (0.42) | MEN1KMT2ABIDMCL1TLR8 | |
| SCHEMBL1024836 | 0.89 | CYP3A4 (0.43) | MEN1KMT2ABIDMCL1TLR8 | |
| SCHEMBL11692367 | 0.85 | HPGD (0.44) | MEN1KMT2ATLR8CYP3A4TSHR | |
| SCHEMBL15536512 | 0.82 | KMT2A (0.46) | MEN1KMT2ACYP3A4TSHRTDP1 | |
| SCHEMBL1576754 | 0.79 | KMT2A (0.59) | MEN1KMT2ACYP3A4TSHRTDP1 | |
| SCHEMBL10785650 | 0.79 | KMT2A (0.59) | MEN1KMT2ACYP3A4TSHRTDP1 | |
| SCHEMBL10789790 | 0.79 | KMT2A (0.59) | MEN1KMT2ACYP3A4TSHRTDP1 | |
| SCHEMBL9815019 | 0.79 | TLR8 (0.39) | MEN1KMT2ATLR8CYP3A4TSHR | |
| SCHEMBL3747524 | 0.78 | MEN1 (0.45) | MEN1KMT2ATLR8CYP3A4TSHR | |
| Pyrene SCHEMBL4416467 | 0.78 | MEN1 (0.45) | MEN1KMT2ATLR8CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150299763-A1 | SPLA2 CARDIOVASCULAR PROGNOSTIC AND DIAGNOSTIC MARKER | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2015-10-22 | — | — | US | disclosed |
| US-8187818-B2 | Use of sPLA2 activity for the diagnosis of a cardiovascular event | Assistance Publique—Hopitaux de Paris (FR) | 2012-05-29 | — | — | US | disclosed |
| EP-2360268-A1 | Use of SPLA2 activity for the diagnosis of a cardiovascular event | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2011-08-24 | — | — | EP | disclosed |
| EP-2046977-B1 | USE OF SPLA2 ACTIVITY FOR THE DIAGNOSIS OF A CARDIOVASCULAR EVENT | INST NAT SANTE RECH MED (FR) | 2011-07-06 | — | — | EP | disclosed |
| US-20090325194-A1 | USE OF SPLA2 ACTIVITY FOR THE DIAGNOSIS OF A CARDIOVASCULAR EVENT | ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (FR) | 2009-12-31 | — | — | US | disclosed |
| EP-2077332-A1 | Secretory phospholipase A2 (sPLA2) as prognostic and diagnostic marker for cardiovascular diseases | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2009-07-08 | — | — | EP | disclosed |
| EP-2046977-A1 | USE OF SPLA2 ACTIVITY FOR THE DIAGNOSIS OF A CARDIOVASCULAR EVENT | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008015546-A1 | USE OF SPLA2 ACTIVITY FOR THE DIAGNOSIS OF A CARDIOVASCULAR EVENT | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2008-02-07 | — | — | WO | disclosed |
| EP-1884571-A1 | Use of spla2 activity for the diagnosis of a cardiovascular event | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2008-02-06 | — | — | EP | disclosed |
| US-20070249008-A1 | Cardiovascular Prognostic and Diagnostic Marker | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 2007-10-25 | — | — | US | disclosed |
| EP-1769083-A2 | SECRETORY PHOSPHOLIPASE A2 (SPLA2) AS PROGNOSTIC AND DIAGNOSTIC MARKER FOR CARDIOVASCULAR DISEASES | I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale (FR) | 2007-04-04 | — | — | EP | disclosed |
| WO-2006008088-A2 | SECRETORY PHOSPHOLIPASE A2 (SPLA2) AS PROGNOSTIC AND DIAGNOSTIC MARKER FOR CARDIOVASCULAR DISEASES | I.N.S.E.R.M. (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2006-01-26 | — | — | WO | disclosed |