Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | MAOB | P27338 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.60 |
| ▸ | NAMPT | P43490 | 7/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.53 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4357696 | 0.89 | NAMPT (0.59) | RAB9APOLBNPC1MAOBNAMPT | |
| SCHEMBL4347646 | 0.87 | MTOR (0.70) | RAB9APOLBPRMT3NAMPTSMN1; SMN2 | |
| SCHEMBL16946645 | 0.78 | NPC1 (0.84) | RAB9APOLBNPC1MAOBALDH1A1 | |
| SCHEMBL26546719 | 0.78 | RAB9A (0.73) | RAB9APOLBNPC1MAOBALDH1A1 | |
| SCHEMBL8180564 | 0.77 | RAB9A (0.88) | RAB9APOLBNPC1MAOBALDH1A1 | |
| SCHEMBL7420189 | 0.77 | RAB9A (1.00) | RAB9APOLBNPC1MAOBALDH1A1 | |
| SCHEMBL108218 | 0.77 | ERCC1 (0.78) | RAB9APOLBNPC1SMN1; SMN2KMT2A | |
| SCHEMBL1137106 | 0.77 | MET (0.53) | POLBALDH1A1SMN1; SMN2GAAKMT2A | |
| SCHEMBL23747565 | 0.77 | RAB9A (0.71) | RAB9APOLBNPC1MAOBALDH1A1 | |
| Hydrochloric Acid SCHEMBL322141 | 0.77 | MEN1 (0.49) | RAB9ANPC1ALDH1A1NAMPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110862398-B | Urea substituted aromatic ring-linked dioxane quinazoline or quinoline compound, composition and application thereof | 北京赛特明强医药科技有限公司 | 2021-04-06 | — | — | CN | disclosed |
| CN-110862398-A | Urea substituted aromatic ring-linked dioxane quinazoline or quinoline compound, composition and application thereof | 北京赛特明强医药科技有限公司 | 2020-03-06 | — | — | CN | disclosed |
| WO-2020042972-A1 | UREA-SUBSTITUTED AROMATIC RING-LINKED DIOXANE AND QUINAZOLINE OR QUINOLINE COMPOUND, COMPOSITION AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2020-03-05 | — | — | WO | disclosed |
| WO-2020042972-A1 | UREA-SUBSTITUTED AROMATIC RING-LINKED DIOXANE AND QUINAZOLINE OR QUINOLINE COMPOUND, COMPOSITION AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2020-03-05 | — | — | WO | disclosed |