Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.70 |
| ▸ | NAMPT | P43490 | 3/20 | 0.62 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.61 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.49 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4348348 | 0.87 | MTOR (0.69) | MTORNAMPTPRMT3TRPV1MCHR1 | |
| SCHEMBL21776629 | 0.87 | RAB9A (0.63) | MTORNAMPTPRMT3ERCC1ERCC4 | |
| SCHEMBL4348431 | 0.86 | MTOR (0.68) | MTORNAMPTPRMT3TRPV1MCHR1 | |
| SCHEMBL4354013 | 0.85 | MEN1 (0.64) | MTORMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL4357696 | 0.84 | NAMPT (0.59) | NAMPTCA1CA2CA9MEN1 | |
| SCHEMBL4346879 | 0.82 | MTOR (0.62) | MTORNAMPTPRMT3TRPV1MCHR1 | |
| SCHEMBL26625460 | 0.81 | MTOR (0.71) | MTORNAMPTPRMT3TRPV1MEN1 | |
| SCHEMBL28808075 | 0.78 | MTOR (0.76) | MTORNAMPTPRMT3CA1CA2 | |
| SCHEMBL4353993 | 0.78 | MTOR (0.67) | MTORNAMPTPRMT3TRPV1CA1 | |
| SCHEMBL4350068 | 0.78 | MTOR (0.67) | MTORNAMPTPRMT3TRPV1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100546977-C | Suppress the new compound and the application thereof of rotamase | JERINI AG (DE) | 2009-10-07 | — | — | CN | claimed |
| EP-2100876-A2 | New compounds for the inhibition of rotamases and use thereof | Jerini AG (DE) | 2009-09-16 | — | — | EP | claimed |
| CN-1701061-A | Novel compounds for inhibiting rotamase enzymes and uses thereof | JERINI AG (DE) | 2005-11-23 | — | — | CN | claimed |
| EP-2100876-A2 | New compounds for the inhibition of rotamases and use thereof | Jerini AG (DE) | 2009-09-16 | — | — | EP | disclosed |