Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 9/20 | 0.47 |
| ▸ | SNCA | P37840 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 9/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 9/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30412738 | 1.00 | NOTUM (0.47) | NOTUMSNCABACE1BACE2 | |
| SCHEMBL30412745 | 0.87 | NOTUM (0.62) | NOTUMSNCABACE1BACE2 | |
| SCHEMBL23451601 | 0.87 | NOTUM (0.62) | NOTUMSNCABACE1BACE2 | |
| SCHEMBL21776788 | 0.77 | NOTUM (0.64) | NOTUMBACE1BACE2 | |
| SCHEMBL21777025 | 0.76 | NOTUM (0.58) | NOTUMSNCABACE1 | |
| SCHEMBL30413359 | 0.76 | NOTUM (0.58) | NOTUMSNCABACE1 | |
| SCHEMBL23451539 | 0.76 | NOTUM (0.65) | NOTUMSNCA | |
| SCHEMBL21792032 | 0.74 | NOTUM (0.62) | NOTUMSNCA | |
| SCHEMBL21776892 | 0.73 | NOTUM (0.61) | NOTUMSNCA | |
| SCHEMBL21776998 | 0.73 | NOTUM (0.61) | NOTUMSNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | UCL BUSINESS LTD (GB) | 2023-04-25 | — | — | US | disclosed |
| EP-3843844-A1 | COMPOUNDS | UCL Business Ltd (GB) | 2021-07-07 | — | — | EP | disclosed |
| US-20210171475-A1 | COMPOUNDS | UCL BUSINESS LTD (GB) | 2021-06-10 | — | — | US | disclosed |
| US-20210171475-A1 | COMPOUNDS | UCL BUSINESS LTD (GB) | 2021-06-10 | — | — | US | disclosed |
| WO-2020043866-A1 | COMPOUNDS | UCL BUSINESS LTD (GB) | 2020-03-05 | — | — | WO | disclosed |
| WO-2020043866-A1 | COMPOUNDS | UCL BUSINESS LTD (GB) | 2020-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | NOTUM, GOT2, GOT1 | NOTUM 1/4885SNCA 4155/4885BACE1 2172/4885 |
| US-20210171475-A1 | COMPOUNDS | GOT2, GOT1, OAT | NOTUM 5/4885SNCA 1217/4885BACE1 708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.