Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.69 |
| ▸ | NPC1 | O15118 | 7/20 | 0.69 |
| ▸ | RAB9A | P51151 | 7/20 | 0.69 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.66 |
| ▸ | TP53 | P04637 | 4/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11674120 | 0.87 | SMN1; SMN2 (0.89) | HPGDSMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL13882293 | 0.85 | SMN1; SMN2 (0.85) | HPGDSMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL16675211 | 0.83 | SMN1; SMN2 (0.82) | HPGDSMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL12974 | 0.81 | HPGD (0.73) | HPGDSMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL23451871 | 0.81 | NOTUM (0.47) | HPGDSMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL12634931 | 0.80 | NPC1 (0.83) | HPGDSMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL21778135 | 0.79 | NOTUM (0.53) | HPGDSMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL21776967 | 0.79 | NPC1 (0.69) | HPGDSMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL2835027 | 0.79 | MECP2 (0.69) | HPGDSMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL14112948 | 0.79 | SMN1; SMN2 (0.69) | HPGDSMN1; SMN2NPC1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | UCL BUSINESS LTD (GB) | 2023-04-25 | — | — | US | disclosed |
| EP-3843844-A1 | COMPOUNDS | UCL Business Ltd (GB) | 2021-07-07 | — | — | EP | disclosed |
| US-20210171475-A1 | COMPOUNDS | UCL BUSINESS LTD (GB) | 2021-06-10 | — | — | US | disclosed |
| WO-2020043866-A1 | COMPOUNDS | UCL BUSINESS LTD (GB) | 2020-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | NOTUM, GOT2, GOT1 | HPGD 632/4885SMN1; SMN2 451/4885NPC1 51/4885 |
| US-20210171475-A1 | COMPOUNDS | GOT2, GOT1, OAT | HPGD 1075/4885SMN1; SMN2 74/4885NPC1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.