Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 5/20 | 0.34 |
| ▸ | CA2 | P00918 | 5/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL50639 | 0.81 | HTR1A (0.39) | MEN1KMT2ANPC1RAB9ACA1 | |
| SCHEMBL27174831 | 0.81 | KMT2A (0.39) | MEN1KMT2APTGS2NPC1RAB9A | |
| SCHEMBL19475490 | 0.78 | CA2 (0.34) | CA1CA2CA12CA4CA7 | |
| SCHEMBL3138923 | 0.71 | CA2 (0.40) | CA1CA2CA12CA4CA7 | |
| SCHEMBL23531760 | 0.71 | CA2 (0.34) | PTGS2PTGS1CA1CA2CA12 | |
| SCHEMBL9365275 | 0.69 | CA2 (0.36) | CA1CA2CA12CA4CA7 | |
| SCHEMBL9095722 | 0.69 | NOS1 (0.46) | MEN1KMT2APTGS2NPC1RAB9A | |
| SCHEMBL245790 | 0.69 | SMN1; SMN2 (0.44) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL2711942 | 0.68 | MEN1 (0.38) | MEN1KMT2A | |
| SCHEMBL6137289 | 0.66 | IDH1 (0.36) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3844158-A1 | HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS SODIUM CHANNEL INHIBITORS | Xenon Pharmaceuticals Inc. (CA) | 2021-07-07 | — | — | EP | claimed |
| WO-2020047312-A1 | HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS SODIUM CHANNEL INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2020-03-05 | — | — | WO | claimed |