Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 5/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | LSS | P48449 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21829475 | 0.87 | MAPT (0.43) | P2RX7PPARAPPARG | |
| SCHEMBL21777929 | 0.75 | EPHX2 (0.43) | P2RX7PPARAPPARGEPHX2MAPK14 | |
| SCHEMBL6921088 | 0.72 | LSS (0.48) | P2RX7PPARAPPARGEPHX2MAPK14 | |
| SCHEMBL21777963 | 0.70 | TEAD1 (0.47) | P2RX7KCNH2TEAD1HRH3 | |
| SCHEMBL21777965 | 0.70 | TEAD1 (0.47) | P2RX7KCNH2TEAD1HRH3 | |
| SCHEMBL21830210 | 0.70 | MAPT (0.44) | — | |
| SCHEMBL21778023 | 0.70 | KCNH2 (0.41) | PPARAPPARGEPHX2KCNH2TEAD1 | |
| SCHEMBL29116611 | 0.69 | ACE (0.39) | PPARAPPARGEPHX2MAPK14FFAR1 | |
| SCHEMBL28564046 | 0.68 | P2RX7 (0.45) | P2RX7PPARAPPARGEPHX2KCNH2 | |
| SCHEMBL29196384 | 0.67 | ALDH1A1 (0.47) | PPARAPPARGEPHX2MAPK14KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3843842-A1 | CARDIAC SARCOMERE INHIBITORS | Cytokinetics, Inc. (US) | 2021-07-07 | — | — | EP | disclosed |
| WO-2020047447-A1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS, INC. (US) | 2020-03-05 | — | — | WO | disclosed |