SCHEMBL21780127

SCHEMBL21780127

CC(C)(C)OC(=O)NC/C(=C/F)COc1ccc(C(=O)N2CCc3ccccc3[C@@H]2c2ccccc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CA12 O43570 7/20 0.45
CA1 P00915 7/20 0.45
CA2 P00918 7/20 0.45
CA7 P43166 7/20 0.45
CA9 Q16790 7/20 0.45
CA14 Q9ULX7 7/20 0.45
HHAT Q5VTY9 3/20 0.42
ESR1 P03372 1/20 0.42
ESR2 Q92731 1/20 0.42
CYP2D6 P10635 1/20 0.42
TRPM8 Q7Z2W7 4/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
DRD2 P14416 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21780130 0.83 KMT2A (0.47) CYP2D6DRD2
Trifluoroacetic Acid SCHEMBL28901212 0.81 CA12 (0.47) CA12CA1CA2CA7CA9
SCHEMBL21780054 0.75 AOC3 (0.50) CA12CA1CA2CA9
SCHEMBL21768043 0.75 AOC3 (0.50) CA12CA1CA2CA9
SCHEMBL23718599 0.75 AOC3 (0.50) CA12CA1CA2CA9
SCHEMBL21780050 0.73 AOC3 (0.49) HDAC1HDAC8
SCHEMBL21780085 0.73 CA1 (0.40) CA1CA2CA7CA9CA14
SCHEMBL21768135 0.72 AOC3 (0.49) CA12CA1CA2CA9
SCHEMBL21780044 0.72 AOC3 (0.49) CA12CA1CA2CA9
SCHEMBL23718635 0.72 AOC3 (0.49) CA12CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3617186-A1 FLUOROALLYLAMINE DERIVATIVE AND USE THEREOF Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) 2020-03-04 EP disclosed