SCHEMBL21780871

SCHEMBL21780871

COc1ccc(O)cc1SC=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 2/20 0.47
MAOB P27338 2/20 0.46
CAPN1 P07384 2/20 0.45
ERN1 O75460 4/20 0.44
ALDH1A1 P00352 4/20 0.43
AOX1 Q06278 1/20 0.43
APP P05067 2/20 0.41
TDP1 Q9NUW8 3/20 0.40
HPGD P15428 2/20 0.40
TRIM24 O15164 1/20 0.40
ALDH5A1 P51649 1/20 0.40
ABAT P80404 1/20 0.40
TRIM33 Q9UPN9 1/20 0.40
TSHR P16473 1/20 0.39
MAPT P10636 2/20 0.39
PARP1 P09874 1/20 0.39
MAOA P21397 1/20 0.39
CTSL P07711 1/20 0.39
CTSB P07858 1/20 0.39
CYP1A1 P04798 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5878690 0.77 MAOB (0.52) BACE1MAOBCAPN1ALDH1A1TDP1
SCHEMBL29953580 0.76 BACE1 (0.60) BACE1MAOBCAPN1ERN1ALDH1A1
SCHEMBL1647101 0.76 BACE1 (0.60) BACE1MAOBCAPN1ERN1ALDH1A1
SCHEMBL12656573 0.73 CA1 (0.48) ERN1ALDH1A1TDP1TSHRCYP1A1
SCHEMBL21780930 0.71 MAOB (0.50) MAOBERN1ALDH1A1TDP1MAPT
SCHEMBL30514387 0.69 MAOB (0.70) MAOBALDH1A1TDP1HPGDTSHR
SCHEMBL119396 0.69 MAOB (0.70) MAOBALDH1A1TDP1HPGDTSHR
SCHEMBL14242940 0.69 ALDH1A1 (0.45) ALDH1A1AOX1APPTDP1HPGD
SCHEMBL37462 0.68 ALDH1A1 (0.63) MAOBCAPN1ERN1ALDH1A1APP
Acetaldehyde SCHEMBL669161 0.68 MAOB (0.80) BACE1MAOBALDH1A1APPTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3233828-B1 ESTROGEN RECEPTOR MODULATORS AND USES THEREOF HOFFMANN LA ROCHE (CH) 2020-03-04 EP disclosed