Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17845095 | 0.82 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1PTGS2NPC1RAB9A | |
| SCHEMBL17845084 | 0.78 | GPBAR1 (0.44) | HSP90AA1HSP90AB1LMNANPSR1NPC1 | |
| SCHEMBL21780774 | 0.77 | GPBAR1 (0.46) | HSP90AA1LMNANPSR1PTGS2NPC1 | |
| SCHEMBL17845090 | 0.77 | L3MBTL1 (0.49) | HSP90AA1HSP90AB1LMNANPSR1NPC1 | |
| SCHEMBL17845139 | 0.70 | CNR1 (0.43) | HSP90AA1HSP90AB1LMNANPSR1PTGS2 | |
| SCHEMBL5681041 | 0.69 | ABL1 (0.60) | NPC1RAB9AL3MBTL1PTPN1MAPT | |
| SCHEMBL11755156 | 0.66 | LMNA (0.48) | LMNANPSR1PTGS2NPC1RAB9A | |
| SCHEMBL17845183 | 0.66 | APP (0.44) | PTGS2NPC1RAB9AL3MBTL1PIK3CD | |
| SCHEMBL19123777 | 0.64 | MAPT (0.43) | PTGS2L3MBTL1ALOX5MAPTGRM1 | |
| SCHEMBL7897510 | 0.64 | ABL1 (0.46) | HSP90AA1HSP90AB1LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233828-B1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2020-03-04 | — | — | EP | disclosed |