Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 4/20 | 0.36 |
| ▸ | APP | P05067 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24831602 | 0.81 | ACHE (0.41) | ALDH1A1ACHEAPPBCHEPIM2 | |
| SCHEMBL15883615 | 0.78 | ACHE (0.52) | ALDH1A1ACHEAPPBCHEPIM2 | |
| SCHEMBL20368694 | 0.74 | CCNT1 (0.42) | ALDH1A1ACHEAPPBCHE | |
| SCHEMBL21781486 | 0.73 | ALDH1A1 (0.37) | ALDH1A1ATMMAPTROCK2ROCK1 | |
| SCHEMBL21781356 | 0.73 | KDM4E (0.30) | SMN1; SMN2 | |
| SCHEMBL21781663 | 0.72 | GRM5 (0.54) | BCHE | |
| SCHEMBL21781403 | 0.72 | ACHE (0.40) | ACHEAPPBCHEHPGDROCK2 | |
| SCHEMBL15571635 | 0.72 | AR (0.43) | ACHEAPPBCHEROCK2ROCK1 | |
| SCHEMBL21781478 | 0.71 | ALDH1A1 (0.35) | ALDH1A1PIM2 | |
| SCHEMBL22853622 | 0.69 | ABL1 (0.38) | ACHEAPPBCHEPIM2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2945939-B1 | THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE HOLDINGS CORP (US) | 2020-03-04 | — | — | EP | disclosed |