SCHEMBL21781814

SCHEMBL21781814

COC(C(C)C(=O)NC(C)C(=O)NCc1ccc(NC(=O)C(CCCNC(N)=O)NC(=O)CNC(=O)CCCN2CCC(C(N)=O)CC2C(F)(F)F)cc1)C1CCCN1C

nearest known ligand 0.31

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
AKT1 P31749 2/20 0.31
ITGB1 P05556 1/20 0.30
ITGA5 P08648 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21781797 0.93 AKT1 (0.39) AKT1ITGB1ITGA5
SCHEMBL21781807 0.88 CYP3A4 (0.31) AKT1ITGB1
SCHEMBL21782018 0.87 AKT1 (0.37) AKT1ITGB1ITGA5
SCHEMBL21781887 0.83
SCHEMBL21781742 0.82 MMP7 (0.32) ITGB1ITGA5
SCHEMBL21782113 0.80 AKT1 (0.41) AKT1ITGB1ITGA5
SCHEMBL21782075 0.80 AKT1 (0.40) AKT1ITGB1ITGA5
SCHEMBL21781926 0.79 AKT1 (0.42) AKT1ITGB1ITGA5
SCHEMBL21781948 0.79 AKT1 (0.41) AKT1ITGB1ITGA5
SCHEMBL21781748 0.76 KMT2A (0.31) ITGB1ITGA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3617221-A1 CYTOTOXIN AND CONJUGATE, USES OF SAME, AND PREPARATION METHOD THEREFOR Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) 2020-03-04 EP disclosed