Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 4/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15014481 | 1.00 | ALDH1A1 (0.38) | ALDH1A1JAK1JAK2TYK2JAK3 | |
| SCHEMBL1190555 | 0.89 | — | — | |
| SCHEMBL5831087 | 0.89 | JAK1 (0.39) | ALDH1A1JAK1JAK2TYK2JAK3 | |
| SCHEMBL12424641 | 0.88 | TSHR (0.38) | ALDH1A1JAK1JAK2TYK2JAK3 | |
| SCHEMBL23889394 | 0.85 | TSHR (0.36) | JAK1JAK2TYK2JAK3TSHR | |
| SCHEMBL21781847 | 0.83 | JAK1 (0.38) | JAK1JAK2TYK2JAK3DPP4 | |
| SCHEMBL21089261 | 0.83 | JAK1 (0.36) | ALDH1A1JAK1JAK2TYK2JAK3 | |
| SCHEMBL23889536 | 0.82 | JAK2 (0.30) | JAK1JAK2 | |
| SCHEMBL12424474 | 0.81 | THRB (0.31) | — | |
| SCHEMBL2751529 | 0.80 | SMN1; SMN2 (0.39) | JAK1JAK2KDM4EDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3617221-A1 | CYTOTOXIN AND CONJUGATE, USES OF SAME, AND PREPARATION METHOD THEREFOR | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2020-03-04 | — | — | EP | disclosed |