Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 4/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5831087 | 0.93 | JAK1 (0.39) | JAK1JAK2TYK2JAK3DPP4 | |
| SCHEMBL1190555 | 0.93 | — | — | |
| SCHEMBL2751529 | 0.84 | SMN1; SMN2 (0.39) | JAK1JAK2DPP4 | |
| SCHEMBL6977767 | 0.84 | — | — | |
| SCHEMBL21782065 | 0.83 | ALDH1A1 (0.38) | JAK1JAK2TYK2JAK3DPP4 | |
| SCHEMBL21781847 | 0.83 | JAK1 (0.38) | JAK1JAK2TYK2JAK3DPP4 | |
| SCHEMBL9342162 | 0.83 | JAK1 (0.35) | JAK1JAK2TYK2JAK3DPP4 | |
| SCHEMBL15014481 | 0.83 | ALDH1A1 (0.38) | JAK1JAK2TYK2JAK3DPP4 | |
| SCHEMBL3167403 | 0.82 | DPP4 (0.40) | DPP4ALDH1A1HSD17B10 | |
| SCHEMBL6160369 | 0.82 | DPP4 (0.40) | DPP4ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286172-B1 | LSD1 INHIBITORS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS INC (US) | 2019-06-12 | — | — | EP | disclosed |