Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 16/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 16/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 15/20 | 0.44 |
| ▸ | SCN1B | Q07699 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21783448 | 0.90 | SCN8A (0.42) | SCN1ASCN8ASCN5ASCN1BMEN1 | |
| SCHEMBL21783325 | 0.76 | CASP6 (0.44) | SCN1ASCN8ASCN5ASCN1BL3MBTL1 | |
| SCHEMBL21783441 | 0.68 | SCN8A (0.43) | SCN1ASCN8ASCN5ASCN1BMEN1 | |
| SCHEMBL20256561 | 0.68 | SCN8A (0.43) | SCN1ASCN8ASCN5ASCN1BNR1I2 | |
| SCHEMBL20256512 | 0.67 | SCN8A (0.50) | SCN1ASCN8ASCN5ASCN1BNR1I2 | |
| SCHEMBL21783342 | 0.67 | SCN8A (0.38) | SCN1ASCN8ASCN5ASCN1BMEN1 | |
| SCHEMBL20256423 | 0.65 | SCN1A (0.66) | SCN1ASCN8ASCN5A | |
| SCHEMBL20256732 | 0.63 | SCN8A (0.43) | SCN1ASCN8ASCN5ASCN1BNR1I2 | |
| SCHEMBL20256604 | 0.63 | SCN8A (0.50) | SCN1ASCN8ASCN5ASCN1BNR1I2 | |
| SCHEMBL20256695 | 0.63 | SCN8A (0.78) | SCN1ASCN8ASCN5ASCN1BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047323-A1 | HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2020-03-05 | — | — | WO | disclosed |