Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.53 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25260940 | 0.79 | GPR119 (0.58) | GPR119RIPK1CHEK1CHEK2LRRK2 | |
| SCHEMBL30339666 | 0.79 | GPR119 (0.58) | GPR119RIPK1CHEK1CHEK2LRRK2 | |
| SCHEMBL16635426 | 0.77 | GPR119 (0.53) | GPR119RIPK1CHEK1CHEK2KCNH2 | |
| SCHEMBL29324694 | 0.77 | SMN1; SMN2 (0.49) | GPR119RIPK1CHEK1CHEK2KDR | |
| SCHEMBL3617657 | 0.76 | GPR119 (0.58) | GPR119RIPK1CHEK1CHEK2KCNH2 | |
| SCHEMBL4555152 | 0.76 | GPR119 (0.70) | GPR119RIPK1CHEK1CHEK2KCNH2 | |
| SCHEMBL3486651 | 0.75 | GPR119 (0.57) | GPR119RIPK1CHEK1CHEK2KCNH2 | |
| SCHEMBL27226303 | 0.74 | KDR (0.53) | GPR119RIPK1CHEK1KDRHRH4 | |
| SCHEMBL20337973 | 0.74 | GPR119 (0.53) | GPR119RIPK1CHEK1 | |
| SCHEMBL10316047 | 0.73 | GPR119 (0.55) | GPR119RIPK1CHEK1CHEK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020043173-A1 | HETEROCYCLIC COMPOUND AS RECEPTOR INTERACTING PROTEIN 1(RIP1) KINASE INHIBITOR | 宁波文达医药科技有限公司 | 2020-03-05 | — | — | WO | disclosed |