Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 5/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15339573 | 0.82 | GRIN2B (0.41) | MAP3K5JAK1GRM2JAK2TYK2 | |
| SCHEMBL21783643 | 0.79 | GRM2 (0.40) | MAP3K5JAK1GRM2JAK2TYK2 | |
| SCHEMBL7859822 | 0.79 | HTR7 (0.42) | MAP3K5JAK1GRM2JAK2TYK2 | |
| SCHEMBL21783749 | 0.79 | JAK1 (0.39) | MAP3K5JAK1GRM2JAK2TYK2 | |
| SCHEMBL21783728 | 0.79 | MAP3K5 (0.36) | MAP3K5JAK1GRM2JAK2TYK2 | |
| SCHEMBL24729940 | 0.77 | GRIN2B (0.43) | MAP3K5JAK1GRM2JAK2TYK2 | |
| SCHEMBL23937881 | 0.77 | PARP1 (0.37) | MAP3K5GRM2 | |
| SCHEMBL21704234 | 0.75 | KMT2A (0.43) | JAK2TYK2JAK3 | |
| SCHEMBL23938080 | 0.74 | GRIN2B (0.43) | MAP3K5JAK1GRM2JAK2GRIN2B | |
| SCHEMBL20731030 | 0.74 | CYP1A2 (0.38) | JAK1GRM2JAK2GRIN2BKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047208-A1 | INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN | MORPHIC THERAPEUTIC, INC. (US) | 2020-03-05 | — | — | WO | disclosed |