Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 5/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15339573 | 0.81 | GRIN2B (0.41) | JAK1JAK2TYK2MAP3K5GABRG2 | |
| SCHEMBL21783750 | 0.79 | MAP3K5 (0.39) | JAK1JAK2TYK2MAP3K5GABRG2 | |
| SCHEMBL7859822 | 0.78 | HTR7 (0.42) | JAK1JAK2TYK2MAP3K5HDAC6 | |
| SCHEMBL21783643 | 0.78 | GRM2 (0.40) | JAK1JAK2TYK2MAP3K5HDAC6 | |
| SCHEMBL21783728 | 0.78 | MAP3K5 (0.36) | JAK1JAK2TYK2MAP3K5HDAC6 | |
| SCHEMBL24729940 | 0.76 | GRIN2B (0.43) | JAK1JAK2TYK2MAP3K5GRIN2B | |
| SCHEMBL23938080 | 0.73 | GRIN2B (0.43) | JAK1JAK2MAP3K5HDAC6GRIN2B | |
| SCHEMBL20731030 | 0.73 | CYP1A2 (0.38) | JAK1JAK2HDAC6GRIN2BGRM2 | |
| SCHEMBL30794117 | 0.73 | ALDH1A1 (0.41) | JAK1JAK2TYK2MAP3K5GRM2 | |
| SCHEMBL15712202 | 0.72 | PKM (0.38) | JAK1JAK2HDAC6GRIN2BGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047208-A1 | INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN | MORPHIC THERAPEUTIC, INC. (US) | 2020-03-05 | — | — | WO | disclosed |