SCHEMBL21784518

SCHEMBL21784518

Oc1cc(O)c(-c2cccc(Cl)c2F)cc1-c1ccccc1F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NMUR2 Q9GZQ4 1/20 0.41
GPR35 Q9HC97 1/20 0.40
KMO O15229 2/20 0.39
ELANE P08246 1/20 0.38
KDM4E B2RXH2 4/20 0.38
ALDH1A1 P00352 3/20 0.38
GLA P06280 1/20 0.38
ACMSD Q8TDX5 1/20 0.37
KMT2A Q03164 3/20 0.37
MEN1 O00255 2/20 0.37
KCNN4 O15554 1/20 0.36
MAPT P10636 3/20 0.36
TDP1 Q9NUW8 2/20 0.36
TTR P02766 1/20 0.36
CYP1A1 P04798 1/20 0.36
CYP3A4 P08684 1/20 0.36
HSPD1 P10809 1/20 0.36
HPGD P15428 1/20 0.36
ALOX15 P16050 1/20 0.36
ALOX12 P18054 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21784645 0.85 MEN1 (0.39) GPR35KDM4EALDH1A1ACMSDKMT2A
SCHEMBL9107868 0.83 ACMSD (0.47) GPR35KDM4EALDH1A1ACMSDKMT2A
SCHEMBL30727464 0.82 ALDH1A1 (0.47) NMUR2KMOKDM4EALDH1A1GLA
SCHEMBL17222493 0.82 ALDH1A1 (0.47) NMUR2KMOKDM4EALDH1A1GLA
SCHEMBL21906401 0.80 NMUR2 (0.46) NMUR2KMOELANEKDM4EKCNN4
SCHEMBL21784527 0.78 MAPK10 (0.45) KDM4EALDH1A1KMT2AMEN1L3MBTL1
SCHEMBL18339172 0.78 NMUR2 (0.41) NMUR2KMOELANEKDM4EALDH1A1
SCHEMBL31621429 0.77 KMO (0.40) NMUR2KMOMAPTHSD17B10NPC1
SCHEMBL18338750 0.77 ACMSD (0.48) GPR35KDM4EACMSDKMT2AMEN1
SCHEMBL931951 0.76 IDO1 (0.44) NMUR2ELANEKDM4EALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220109115-A1 POLYCYCLIC COMPOUND, AND AN ORGANIC ELECTROLUMINESCENCE DEVICE COMPRISING THE POLYCYCLIC COMPOUND IDEMITSU KOSAN CO.,LTD. (JP) 2022-04-07 US disclosed
WO-2020044270-A1 POLYCYCLIC COMPOUND, AND AN ORGANIC ELECTROLUMINESCENCE DEVICE COMPRISING THE POLYCYCLIC COMPOUND IDEMITSU KOSAN CO., LTD. (JP) 2020-03-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220109115-A1 POLYCYCLIC COMPOUND, AND AN ORGANIC ELECTROLUMINESCENCE DEVICE COMPRISING THE POLYCYCLIC COMPOUND ODC1, OTC, PKD1 NMUR2 2177/4885GPR35 2105/4885KMO 1578/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.