Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | MDM4 | O15151 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.45 |
| ▸ | CASP3 | P42574 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30564490 | 0.97 | HDAC1 (0.47) | HDAC1HDAC2MDM4TP53MDM2 | |
| SCHEMBL20852431 | 0.91 | TLR2 (0.50) | HDAC1HDAC2MDM4TP53MDM2 | |
| SCHEMBL30819043 | 0.91 | TLR2 (0.50) | HDAC1HDAC2MDM4TP53MDM2 | |
| SCHEMBL31144370 | 0.90 | KMT2A (0.54) | HDAC1HDAC2MDM4TP53MDM2 | |
| SCHEMBL13385261 | 0.90 | KMT2A (0.45) | HDAC1HDAC2MDM4TP53MDM2 | |
| SCHEMBL25359258 | 0.90 | KMT2A (0.54) | HDAC1HDAC2MDM4TP53MDM2 | |
| SCHEMBL12221104 | 0.90 | TLR2 (0.53) | HDAC1HDAC2MDM4TP53MDM2 | |
| SCHEMBL31004028 | 0.90 | TLR2 (0.53) | HDAC1HDAC2MDM4TP53MDM2 | |
| SCHEMBL25359262 | 0.90 | KMT2A (0.54) | HDAC1HDAC2MDM4TP53MDM2 | |
| SCHEMBL12221123 | 0.90 | TLR2 (0.53) | HDAC1HDAC2MDM4TP53MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220002348-A1 | TAILORED CYCLODEPSIPEPTIDES AS POTENT NON-COVALENT SERINE PROTEASE INHIBITORS | Universität Duisburg-Essen (DE) | 2022-01-06 | — | — | US | disclosed |
| US-11149067-B2 | Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors | Universität Duisburg-Essen (DE) | 2021-10-19 | — | — | US | disclosed |
| US-20200071360-A1 | TAILORED CYCLODEPSIPEPTIDES AS POTENT NON-COVALENT SERINE PROTEASE INHIBITORS | Universität Duisburg-Essen (DE) | 2020-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200071360-A1 | TAILORED CYCLODEPSIPEPTIDES AS POTENT NON-COVALENT SERINE PROTEASE INHIBITORS | HTRA1, LNPEP, ENPEP | HDAC1 3623/4885HDAC2 3929/4885MDM4 3070/4885 |
| US-20220002348-A1 | TAILORED CYCLODEPSIPEPTIDES AS POTENT NON-COVALENT SERINE PROTEASE INHIBITORS | HTRA1, LNPEP, ENPEP | HDAC1 3623/4885HDAC2 3929/4885MDM4 3070/4885 |
| US-11149067-B2 | Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors | HTRA1, LNPEP, ENPEP | HDAC1 3623/4885HDAC2 3929/4885MDM4 3070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.