Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | NAAA | Q02083 | 2/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21786685 | 0.89 | EPHX1 (0.46) | EPHX1GAANR1H4CYP3A4CYP2C19 | |
| SCHEMBL16690968 | 0.81 | EPHX1 (0.54) | EPHX1GAANAAAACHEBCHE | |
| SCHEMBL22009225 | 0.81 | EPHX1 (0.44) | EPHX1GAANR1H4TSHRBRD4 | |
| SCHEMBL26935459 | 0.80 | EPHX1 (0.43) | EPHX1GAANR1H4HDAC4HDAC1 | |
| SCHEMBL29356714 | 0.80 | EPHX1 (0.47) | EPHX1GAAHDAC1TSHRBRD4 | |
| SCHEMBL24263885 | 0.79 | GAA (0.58) | EPHX1GAANAAAACHEBCHE | |
| SCHEMBL21261851 | 0.79 | EPHX1 (0.46) | EPHX1GAAHDAC1BRD4SMN1; SMN2 | |
| SCHEMBL27076459 | 0.79 | EPHX1 (0.46) | EPHX1GAAHDAC4HDAC1BRD4 | |
| SCHEMBL27076413 | 0.79 | EPHX1 (0.46) | EPHX1GAAHDAC4HDAC1BRD4 | |
| SCHEMBL19962463 | 0.78 | EPHX1 (0.72) | EPHX1GAAHDAC1CYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200069717-A1 | NUCLEOTIDE DERIVATIVES AND METHODS OF USE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200069717-A1 | NUCLEOTIDE DERIVATIVES AND METHODS OF USE THEREOF | POLRMT, NSUN2, RNGTT | EPHX1 2734/4885GAA 1073/4885NR1H4 3101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.