Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18767445 | 0.75 | CDK8 (0.35) | CHEK1MAP4K4CSF1RPRKACAKDR | |
| SCHEMBL22891871 | 0.69 | NOTUM (0.36) | CHEK1MAP4K4CSF1RPRKACAKDR | |
| SCHEMBL1417158 | 0.67 | KDM4E (0.55) | CHEK1MAP4K4CSF1RPRKACAKDR | |
| SCHEMBL29965863 | 0.67 | KDM4E (0.55) | CHEK1MAP4K4CSF1RPRKACAKDR | |
| SCHEMBL23546233 | 0.63 | L3MBTL1 (0.52) | — | |
| SCHEMBL18855535 | 0.63 | DRD1 (0.31) | CDK8ROCK1 | |
| SCHEMBL5098191 | 0.62 | FGFR1 (0.38) | CHEK1MAP4K4CSF1RPRKACAKDR | |
| SCHEMBL2360060 | 0.62 | DGAT1 (0.35) | — | |
| SCHEMBL4602967 | 0.62 | ALK (0.38) | CHEK1MAP4K4CSF1RPRKACAKDR | |
| SCHEMBL20759659 | 0.61 | MGAM (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023131978-A1 | IMPROVED PROCESS FOR THE PREPARATION OF UPADACITINIB | MSN LABORATORIES PRIVATE LIMITED, R&D CENTER (IN) | 2023-07-13 | — | — | WO | disclosed |
| EP-3845521-A2 | SYNTHESIS METHODS FOR UPADACITINIB AND INTERMEDIATE THEREOF | Suzhou Pengxu Pharmatech Co., Ltd. (CN) | 2021-07-07 | — | — | EP | disclosed |
| WO-2021123288-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF UPADACITINIB | CRYSTAL PHARMA, S.A.U. (ES) | 2021-06-24 | — | — | WO | disclosed |
| WO-2020043033-A2 | SYNTHESIS METHODS FOR UPADACITINIB AND INTERMEDIATE THEREOF | 苏州鹏旭医药科技有限公司 | 2020-03-05 | — | — | WO | disclosed |