Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 16/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21829639 | 0.83 | METAP2 (0.49) | METAP2HDAC8HDAC6MEN1KMT2A | |
| SCHEMBL30577920 | 0.81 | HDAC8 (0.49) | METAP2HDAC8HDAC6CYP3A4CYP2C19 | |
| SCHEMBL31150920 | 0.73 | HSD11B1 (0.50) | METAP2HDAC8HDAC6MEN1KMT2A | |
| SCHEMBL305455 | 0.71 | HDAC8 (0.50) | METAP2HDAC8HDAC6MEN1KMT2A | |
| SCHEMBL6410939 | 0.70 | HSD11B1 (0.53) | METAP2HDAC8HDAC6MEN1KMT2A | |
| SCHEMBL4002163 | 0.70 | OPRM1 (0.46) | CYP3A4CYP2C19MEN1MAPK1KMT2A | |
| SCHEMBL14817519 | 0.70 | METAP2 (0.51) | METAP2HDAC8HDAC6 | |
| SCHEMBL15374431 | 0.69 | METAP2 (0.57) | METAP2 | |
| SCHEMBL15374437 | 0.69 | METAP2 (0.57) | METAP2 | |
| SCHEMBL15367166 | 0.69 | METAP2 (0.57) | METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047447-A1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS, INC. (US) | 2020-03-05 | — | — | WO | disclosed |