Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 7/20 | 0.68 |
| ▸ | TNKS | O95271 | 5/20 | 0.49 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | C1R | P00736 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13206697 | 0.79 | ELANE (0.66) | ELANETNKSTNKS2KDM4EPARP2 | |
| SCHEMBL3123413 | 0.79 | ELANE (0.54) | ELANETNKSTNKS2KDM4EPARP2 | |
| SCHEMBL15519337 | 0.78 | ELANE (0.68) | ELANECYP1A2KMT2AC1R | |
| SCHEMBL29098687 | 0.78 | KDM4E (0.52) | ELANETNKSTNKS2KDM4EPARP2 | |
| SCHEMBL13100511 | 0.77 | KDM4E (0.49) | ELANETNKSTNKS2KDM4EPARP2 | |
| SCHEMBL8059728 | 0.77 | ELANE (1.00) | ELANEKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL26438946 | 0.75 | KDM4E (0.50) | ELANETNKSTNKS2KDM4EPARP2 | |
| SCHEMBL7424024 | 0.74 | ELANE (0.63) | ELANEKDM4EALDH1A1MEN1CYP1A2 | |
| SCHEMBL6339961 | 0.74 | KDM4E (0.46) | ELANETNKSTNKS2KDM4EPARP2 | |
| SCHEMBL22524940 | 0.74 | ELANE (0.55) | ELANETNKSTNKS2KDM4EPARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3618829-B1 | QUINAZOLINE-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER-RELATED DISORDERS | ARCUS BIOSCIENCES INC (US) | 2023-06-07 | — | — | EP | disclosed |
| US-11045472-B2 | Quinazoline-pyridine derivatives for the treatment of cancer-related disorders | ARCUS BIOSCIENCES, INC. (US) | 2021-06-29 | — | — | US | disclosed |
| US-20200069689-A1 | QUINAZOLINE-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER-RELATED DISORDERS | ARCUS BIOSCIENCES, INC. | 2020-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200069689-A1 | QUINAZOLINE-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER-RELATED DISORDERS | ADORA2A, ADORA2B, ADORA3 | ELANE 3191/4885TNKS 698/4885TNKS2 421/4885 |
| US-11045472-B2 | Quinazoline-pyridine derivatives for the treatment of cancer-related disorders | ADORA2A, ADORA2B, ADORA1 | ELANE 2838/4885TNKS 1066/4885TNKS2 873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.